San Francisco 49ers tight end George Kittle and backup running back Matt Breida both separated their shoulders in the exhibition opener and will miss the rest of the preseason.

Coach Kyle Shanahan said Friday that he expects both players to be ready to return in time for the season opener Sept. 9 at Minnesota.

The Niners lost six players in all to injuries in a 24-21 win over Dallas on Thursday night. Linebacker Malcolm Smith hurt his hamstring and is listed as week to week. Defensive lineman Solomon Thomas and tackle Garry Gilliam are both in the concussion protocol and linebacker Eli Harold is day to day with a bruised knee.

A look at what’s happening around the majors today:

STEPPING DOWN

The Mets march on in their difficult season a day after learning general manager Sandy Alderson had effectively stepped down because his cancer has returned. Officially Sam Darnold Color Rush Jersey , Alderson will take a leave of absence, but he said Tuesday that he was essentially ending his tenure both for his health and because he doesn’t think he’s been successful enough to continue. Assistant general manager John Ricco and special assistants J.P. Ricciardi and Omar Minaya will run the club’s baseball operations in Alderson’s absence. Minaya preceded Alderson as Mets general manager, and Ricciardi was GM of the Toronto Blue Jays from 2001-09.

CAIN NOT ABLE

Lorenzo Cain is missing the chance to face his former teammates this week due to a left groin strain. The Brewers center fielder was placed on the disabled list Tuesday, just as Milwaukee opened a series against Kansas City. Cain left the Royals last offseason for an $80 million Evander Kane Sharks Jersey , five-year deal with the Brewers, and he’s batting .291 with eight homers, 48 RBIs, 16 stolen bases and an .832 OPS for the NL Central leaders.

MADBUM MATH

Madison Bumgarner is one strikeout shy of 1 Orlando Arcia Jersey ,500 for his career going into a start against Colorado. The Giants ace will appear in his 239th game, making him the fourth-fastest left-hander to reach 1,500 Ks in the live-ball era, according to stats. This will be Bumgarner’s fifth start this season Chad Thomas Color Rush Jersey , and he’s 1-2 with a 3.20 ERA.

MAKING BELIEBERS

Indians rookie Shane Bieber is off to a strong start and gets his first interleague test in a game against St. Louis. The right-hander is 2-0 with a 2.45 ERA through three starts, including seven scoreless innings against Detroit last time out. Bieber has 22 strikeouts and three walks in 18 1/3 innings after walking just 18 batters in 274 career minor league innings. The Cardinals will counter with another promising young righty, Jack Flaherty (3-2, 2.50).

HEATING UP

Dallas Keuchel (4-8 Josh Gordon Jersey Elite , 3.90) has been the weakest link in Houston’s rotation – which says more about the Astros than Keuchel – but he’s been sharp of late. Over his past two starts, he’s thrown 12 innings without allowing an earned run, and now he’ll face a Toronto team that struck out 13 times against Charlie Morton in a 7-0 loss Tuesday to Houston.

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